And a highway will be there; it will be called the Way of Holiness. The unclean will not journey on it; it will be for those who walk in that Way; wicked fools will not go about on it.
(I-35, Isaiah 35. Get it?)
It’s unclear to me whether this is a Poe or not, but reading that site is like being beaten over the head with a stick made of frozen crazy.
OTOH, they may be onto something: the 495th line of Isaiah is 26:19, which reads:
But your dead will live; their bodies will rise. You who dwell in the dust, wake up and shout for joy. Your dew is like the dew of the morning; the earth will give birth to her dead.
which sounds a lot like I-495 (the Washington Beltway) to me.
(Tip o’ the tinfoil hat to Martin Wagner.)